Detailed view for TVAG_183300

Basic information

TDR Targets ID: 925316
Trichomonas vaginalis, aminotransferase class V, putative
Source Database / ID: 

pI: 7.5296 | Length (AA): 371 | MW (Da): 41905 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00266   Aminotransferase class-V

Gene Ontology

Mouse over links to read term descriptions.
GO:0004648   phosphoserine transaminase activity  
GO:0003824   catalytic activity  
GO:0006564   L-serine biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 5F8V:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128427)

Species Accession Gene Product
Arabidopsis thaliana AT2G17630   pyridoxal phosphate-dependent transferases superfamily protein
Arabidopsis thaliana AT4G35630   phosphoserine aminotransferase
Candida albicans CaO19.12939   3-phosphoserine transaminase
Candida albicans CaO19.5484   3-phosphoserine transaminase
Caenorhabditis elegans CELE_F26H9.5   Protein F26H9.5
Dictyostelium discoideum DDB_G0269950   phosphoserine aminotransferase
Drosophila melanogaster Dmel_CG11899   CG11899 gene product from transcript CG11899-RA
Escherichia coli b0907   3-phosphoserine/phosphohydroxythreonine aminotransferase
Entamoeba histolytica EHI_026360   phosphoserine aminotransferase, putative
Homo sapiens ENSG00000135069   phosphoserine aminotransferase 1
Mycobacterium leprae ML2136   POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC (PSAT)
Mus musculus 102641810   phosphoserine aminotransferase-like
Mus musculus ENSMUSG00000024640   phosphoserine aminotransferase 1
Mycobacterium tuberculosis Rv0884c   Possible phosphoserine aminotransferase SerC (PSAT)
Mycobacterium ulcerans MUL_0266   phosphoserine aminotransferase
Neospora caninum NCLIV_061600   hypothetical protein
Saccharomyces cerevisiae YOR184W   O-phospho-L-serine:2-oxoglutarate transaminase
Schmidtea mediterranea mk4.000039.03   Probable phosphoserine aminotransferase
Schmidtea mediterranea mk4.034045.02   Phosphoserine aminotransferase
Toxoplasma gondii TGME49_218780   phosphoserine aminotransferase, putative
Trichomonas vaginalis TVAG_224040   phosphoserine aminotransferase, putative
Trichomonas vaginalis TVAG_099570   phosphoserine aminotransferase, putative
Trichomonas vaginalis TVAG_183300   aminotransferase class V, putative

Essentiality

TVAG_183300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu900 Mycobacterium tuberculosis essential nmpdr
b0907 Escherichia coli non-essential goodall
TGME49_218780 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_183300 (Trichomonas vaginalis), aminotransferase class V, putative
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